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KMID : 0043319930160020118
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Archives of Pharmacal Research
1993 Volume.16 No. 2 p.118 ~ p.122
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Effects of n-Alkanols on the Rotational Relaxiation Time of 1,6-Diphenyl-1,3,5-hextriene in the Synaptosomal Plasma Membrane Vesicles Isolated from Bovine Cerebral Cortex
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Chung Yong-Za
Cho Goon-Jae
Yun Il
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Abstract
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The effects of n-alkanols on the rotational relaxation time of 1, 6-dipheny-1, 3, 5-hexatriene (DPH) in synaptosomal plasma membrane vesicles isolate from fresh bovine cerbral contex were investigated. n-Alknols decreased the rotational relaxation time of 1, 6-diphenyl-1, 3, 5-hexatriene in the native membranes and the potencies of n-alkanols up to 1-nonanol increased by 1 order of magnitude as the carbon chain length increases by two carbon atoms, The cut-off phenomenon was reached at 1-decanol, where further increase in hydocabon length resulted in an increase in the rotational relaxation time of DPH in the native membranes.
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KEYWORD
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n-Alkanols, Membrane-disordering effects, Fluroescent prove technique
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